first off all ensure you have no leftover stray memory breakpoints  ollydbg will blink only if it is processing some debug events
running with with f9 should not make it process any event  at all  
you can disable auto analysis of all modules and opt for manual analysis as and when needed 
again it is in alt+o 
you can disable Debugging data loading (or stop all the pdb symbols requests sent to from ms symbol server )
these all could speed up the startup of a large binary
i have an 82 mb udd file of microsoft excel.exe and ollydbg doesnt stall loading or analysing it 
i just loaded it before replying  
loaded excel in a jiffy set a bp on mso#3087 and clicked a cell in excel to break all under a minute max
Code:
Call stack of main thread
Stack     Data              Procedure                                     Called from                                                 Frame
0013F828  3036DAAD          EXCEL.3013F050                                EXCEL.3036DAA8
0013F85C  30799651          EXCEL.3036DA72                                EXCEL.3079964C
0013F9D4  303A68AF          EXCEL.30797EA4                                EXCEL.303A68AA
0013FA94  30016869          ???                                           EXCEL.30016866
0013FB7C  30016767          EXCEL.30016796                                EXCEL.30016762
0013FB9C  7E418734          ???                                           USER32.InternalCallWinProc+25
0013FBC8  7E418816          USER32.InternalCallWinProc                    USER32.UserCallWinProcCheckWow+0B2
0013FC30  7E42A013          USER32.UserCallWinProcCheckWow                USER32.CallWindowProcAorW+4C
0013FC60  7E42A039          USER32.CallWindowProcAorW                     USER32.CallWindowProcW+16
0013FC80  32650ACD          USER32.CallWindowProcW                        mso.32650AC7
0013FCB8  7E418734          ???                                           USER32.InternalCallWinProc+25
0013FCE4  7E418816          USER32.InternalCallWinProc                    USER32.UserCallWinProcCheckWow+0B2
0013FD4C  7E4189CD          USER32.UserCallWinProcCheckWow                USER32.DispatchMessageWorker+0D7
0013FDAC  7E418A10          USER32.DispatchMessageWorker                  USER32.DispatchMessageW+0A
0013FDBC  30027AF5          USER32.DispatchMessageW                       EXCEL.30027AEF
0013FDE0  3002771F          EXCEL.30027A6A                                EXCEL.3002771A
0013FEC4  30003AD8          EXCEL.30026B30                                EXCEL.30003AD3
0013FF34  300037EC          EXCEL.30003802                                EXCEL.300037E7
0013FFC4  7C817077          ???                                           kernel32.BaseProcessStart+20
  
 
Code:
C:\Documents and Settings\Admin\My Documents\ollydbg2beta\odbg201\odbg201>ls -lah EXCEL.udd
-rw-rw-rw-  1 Admin 0 81M 2014-03-25 12:56 EXCEL.udd